Session 4. Modeling Channelopathies

Chair: Said Bendahhou

Anna Weinzinger, University of Vienna
Allosteric control of GIRK channels: insights from channelopathies and drug modulation

Blanca Rodriguez, University of Oxford
Digital Twins for understanding cardiac pathophysiology and treatment response

Marijn B. MARTENS – Synaptica
Functional Effect Predictions For Ion Channel Missense Variants Using a Protein Language Model

Marie LISELOTT MEHLFELDT – Uniklinik RWTH Aachen
Temperature-Dependent Behavior of Nav1.7 and PEPD-associated Mutations: A Combined
Experimental and Computational Study

Elena ZAKLYAZMINSKAYA – Petrovsky National Research Centre of Surgery
Primary ion channel dysfunction as a factor modulating the risk of sudden cardiac death in
patients with hypertrophic cardiomyopathy

Coffee break & poster session

Session 5. Channelopathies in Cancer 

Co-chairs: Isabelle Rubera and Tarik Smani

Raphael Rapetti-Mauss, University of Cote d'Azur
KCNQ1–β-Catenin Interaction: From Epithelial Homeostasis to Cancer Signaling

Dimitra Gkika, University of Lille
TRPM2 channel increases cell viability of triple negative breast cancer cells following chemotherapy through increased mitochondrial activity

Avénie HUET – University of Picardie Jules Verne
Remodelling of normal colon cells proliferation and migration by exposure to pesticide
Chlorpyrifos through Transient Receptor Potential Ankyrin 1 (TRPA1) activation

Giorgia CHINIGÒ – University of Torino
Dynamic endothelial channelopathy driven by breast cancer cells rewires P2X7–PANX-1
signaling to restrain angiogenic migration

Group Pic then Lunch & poster session

Free Afternoon - Choose your activity